化学
芳基
烷基
催化作用
试剂
钴
组分(热力学)
有机化学
格氏试剂
组合化学
药物化学
物理
热力学
作者
Lei Xu,Qian Zhang,Yan‐En Wang,Congcong Bai,Dan Xiong,Jianyou Mao
标识
DOI:10.1021/acs.orglett.4c03453
摘要
A highly regioselective cobalt-catalyzed three-component alkyl arylation of acrylates with alkyl iodides and aryl Grignard reagents has been established. The reaction efficiently provides an alternative strategy for the construction of α-aryl esters with a broad substrate scope and good yields under mild conditions. The practical applicability of this protocol is shown by the scaled-up reaction and further transformations of the products. In addition, the preliminary mechanistic explorations demonstrated that the alkyl radicals generated by the efficient cobalt catalysis are instantaneously added to the acrylates to finally afford the desired products.
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