化学
高价分子
全合成
天然产物
立体化学
衍生工具(金融)
组合化学
试剂
有机化学
经济
金融经济学
作者
Laxmikant D. Gangnale,Chandra Sekhara Rao Boddala,D. Srinivasa Reddy
标识
DOI:10.1021/acs.orglett.4c02619
摘要
This study presents a total synthesis and revision of the stereochemical configuration of a potent antimalarial lead compound 2 possessing a benzo-pyranone framework, which was derived from the (+)-monocerin natural product of marine fungi, Exserohilum sp. Chiral hypervalent iodine(III)-catalyzed oxylactonization and late-stage O-methylation were highlights of the synthesis, which enabled access to the library of all possible eight stereoisomers of 2 for further understanding of stereochemical structure activity relationships (S-SARs).
科研通智能强力驱动
Strongly Powered by AbleSci AI