产黄青霉
生物转化
化学
圆二色性
IC50型
内生真菌在植物防御中的应用
生物测定
体外
立体化学
植物
生物化学
生物
酶
遗传学
作者
Qinghui Zou,Jingjing Wei,zelin chen,Anding Luo,Julie He,Yongling Long,Hui Cui,Yena Liu
标识
DOI:10.1002/cbdv.202401658
摘要
Glaucic acid isolated from the root of Lindera glauca, was investigated by the biotransformation methods via the endophytic fungi, resulting in the production of five new glausesquiterpenes A‒E (1‒5), along with a known analogue 6. Their structures were elucidated based on spectroscopic methods and electronic circular dichroism (ECD) calculations. In the bioassays, glausesquiterpene A (1) showed good inhibitory activity of NO production in LPS‐activated RAW 264.7 macrophages with an IC50 value of 20.1 µM than positive control (Indomethacin, IC50 24.1 µM). Further in vitro studies demonstrated that glausesquiterpene A significantly suppressed the protein expression of iNOS and COX‐2 at the concentration of 25.0 µM.
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