Short Sleep Duration and Hypertension: A Double Hit for the Brain

Background Short sleep duration has been associated with an increased risk of cognitive impairment and dementia. Short sleep is associated with elevated blood pressure, yet the combined insult of short sleep and hypertension on brain health remains unclear. We assessed whether the association of sleep duration with cognition and vascular brain injury was moderated by hypertensive status. Methods and Results A total of 682 dementia‐free participants (mean age, 62±9 years; 53% women) from the Framingham Heart Study completed assessments of cognition, office blood pressure, and self‐reported habitual and polysomnography‐derived sleep duration; 637 underwent brain magnetic resonance imaging. Linear regressions were performed to assess effect modification by hypertensive status on total sleep time (coded in hours) and cognitive and magnetic resonance imaging outcomes. There was a significant interaction between sleep duration and hypertensive status when predicting executive function/processing speed (Trail Making B‐A) and white matter hyperintensities. When results were stratified by hypertensive status, longer sleep duration was associated with better executive functioning/processing speed scores in the hypertensive group (meaning that shorter sleep duration was associated with poorer executive function/processing speed scores) (self‐report sleep: β=0.041 [95% CI, 0.012–0.069], P =0.005; polysomnography sleep: β=0.045 [95% CI, 0.002–0.087], P =0.038), but no association was observed for the normotensive group. Similarly, shorter subjective sleep duration was associated with higher white matter hyperintensity burden in the hypertensive group (β=−0.115 [95% CI, −0.227 to −0.004], P =0.042), but not in the normotensive group. Conclusions In individuals with hypertension, shorter sleep duration was associated with worse cognitive performance and greater brain injury.