孟德尔随机化
线粒体DNA
遗传学
联想(心理学)
生物
拷贝数变化
医学
心理学
基因
基因型
基因组
心理治疗师
遗传变异
作者
Yan’e Lu,Chunsheng Kang,Li Wang,Xiaotong Liu,Xiaojiong Jia,Kunyi Lan,Shumin Gao,Zhendong Feng,Lu-Lu Yu,Jing Wang,Naixue Cui,Ya Bin Wei,Jia Li
标识
DOI:10.1016/j.jad.2024.08.162
摘要
Mitochondria is essential for cellular energy production, oxidative stress, and apoptosis. Mitochondrial DNA (mtDNA) encodes essential proteins for mitochondrial function. Although several studies have explored the association between changes in mtDNA copy number (mtDNA-CN) and risk of mental disorders, the results remain debated. This study used a bidirectional two-sample Mendelian randomization (MR) analysis to examine the genetic causality between mtDNA-CN and mental disorders.
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