Changes in Intra- and Cross-Hemispheric Directed Functional Connectivity in the Electroencephalographic Signals during Propofol-Induced Loss of Consciousness

Numerous, sometimes conflicting, changes in brain functional connectivity have been associated with the transition from wakefulness to unresponsiveness at induction of general anesthesia. However, relatively few studies have looked at: the detailed time evolution of the transition; for different EEG frequency bands; and in the clinical scenario of surgical patients undergoing general anesthesia.