海西定
牙周炎
巨噬细胞极化
牙龈卟啉单胞菌
慢性牙周炎
巨噬细胞
免疫学
医学
微生物学
生物
细胞生物学
炎症
内科学
遗传学
体外
作者
Jinge Dou,Xuan Chen,Jinglan Zhang,Lei Yang,Jie Lin,Wanling Zhu,Dingming Huang,Xuelian Tan
标识
DOI:10.1016/j.intimp.2024.113139
摘要
Hepcidin, a central regulatory molecule of iron metabolism, is upregulated through the IL-6/STAT3 signaling pathway in inflammatory and infectious states, contributing to the pathogenesis of various diseases. In chronic apical periodontitis (CAP), Porphyromonas gingivalis (P. gingivalis) and its lipopolysaccharides (LPS) activate various immune responses in vivo, contributing to disease progression. This study evaluated the role and mechanism of hepcidin in P. gingivalis-induced bone tissue damage in CAP, focusing on its promotion of macrophage M1 polarization via the IL-6/STAT3 signaling pathway.
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