Topical BCl‐2 inhibitor (ABT‐737) attenuates skin photoaging in mice

Experimental DermatologyVolume 33, Issue 3 e15051 RESEARCH LETTER Topical BCl-2 inhibitor (ABT-737) attenuates skin photoaging in mice Bingyi Yang, Bingyi Yang Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, ChinaSearch for more papers by this authorJiao Jiang, Jiao Jiang orcid.org/0000-0002-3916-1712 Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, ChinaSearch for more papers by this authorHaijing Wu, Corresponding Author Haijing Wu [email protected] orcid.org/0000-0002-0389-6848 Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China Correspondence Haijing Wu, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, China. Email: [email protected] Qianjin Lu, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 12, Jiangwangmiao Street, Nanjing, Jiangsu 210042, China. Email: [email protected]Search for more papers by this authorQianjin Lu, Corresponding Author Qianjin Lu [email protected] orcid.org/0000-0002-1504-4896 Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China Correspondence Haijing Wu, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, China. Email: [email protected] Qianjin Lu, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 12, Jiangwangmiao Street, Nanjing, Jiangsu 210042, China. Email: [email protected]Search for more papers by this author Bingyi Yang, Bingyi Yang Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, ChinaSearch for more papers by this authorJiao Jiang, Jiao Jiang orcid.org/0000-0002-3916-1712 Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, ChinaSearch for more papers by this authorHaijing Wu, Corresponding Author Haijing Wu [email protected] orcid.org/0000-0002-0389-6848 Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China Correspondence Haijing Wu, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, China. Email: [email protected] Qianjin Lu, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 12, Jiangwangmiao Street, Nanjing, Jiangsu 210042, China. Email: [email protected]Search for more papers by this authorQianjin Lu, Corresponding Author Qianjin Lu [email protected] orcid.org/0000-0002-1504-4896 Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China Correspondence Haijing Wu, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, China. Email: [email protected] Qianjin Lu, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 12, Jiangwangmiao Street, Nanjing, Jiangsu 210042, China. Email: [email protected]Search for more papers by this author First published: 21 March 2024 https://doi.org/10.1111/exd.15051 Bingyi Yang and Jiao Jiang contributed equally to this work. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. CONFLICT OF INTEREST STATEMENT The authors report no declarations of interest. Open Research DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. REFERENCES 1Pillai S, Oresajo C, Hayward J. Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation - a review. Int J Cosmet Sci. 2005; 27: 17-34. 10.1111/j.1467-2494.2004.00241.x CASPubMedGoogle Scholar 2Kim H, Jang J, Song MJ, et al. Inhibition of matrix metalloproteinase expression by selective clearing of senescent dermal fibroblasts attenuates ultraviolet-induced photoaging. Biomed Pharmacother. 2022; 150:113034. 10.1016/j.biopha.2022.113034 CASPubMedWeb of Science®Google Scholar 3Delbridge AR, Grabow S, Strasser A, Vaux DL. Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies. 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