亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Brain stimulation over the left DLPFC enhances motivation for effortful rewards in patients with major depressive disorder

预测(人工智能) 心理学 背外侧前额叶皮质 脑刺激 刺激 磁刺激 重性抑郁障碍 无动机 神经科学 神经调节 心理信息 前额叶皮质 内在动机 社会心理学 认知 梅德林 人工智能 计算机科学 政治学 法学
作者
Bi Rong,Yanli Zhao,Sijin Li,Feng Xu,Weiwei Peng,Shuping Tan,Dandan Zhang
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:356: 414-423 被引量:3
标识
DOI:10.1016/j.jad.2024.04.064
摘要

Amotivation is a typical feature in major depressive disorder (MDD), which produces reduced willingness to exert effort. The dorsolateral prefrontal cortex (DLPFC) is a crucial structure in goal-directed actions and therefore is a potential target in modulating effortful motivation. However, it remains unclear whether the intervention is effective for patients with MDD. We employed transcranial magnetic stimulation (TMS), computational modelling and event-related potentials (ERPs) to reveal the causal relationship between the left DLPFC and motivation for effortful rewards in MDD. Fifty patients underwent both active and sham TMS sessions, each followed by performing an Effort-Expenditure for Rewards Task, during which participants chose and implemented between low-effort/low-reward and high-effort/high-reward options. The patients showed increased willingness to exert effort for rewards during the DLPFC facilitated session, compared with the sham session. They also had a trend in larger P3 amplitude for motivated attention toward chosen options, larger CNV during preparing for effort exertion, and larger SPN during anticipating a high reward. Besides, while behavior indexes for effortful choices were negatively related to depression severity in the sham session, this correlation was weakened in the active stimulation session. These findings provide behavioral, computational, and neural evidence for the left DLPFC on effortful motivation for rewards. Facilitated DLPFC improves motor preparation and value anticipation after making decisions especially for highly effortful rewards in MDD. Facilitated DLPFC also has a potential function in enhancing motivated attention during cost-benefit trade-off. This neuromodulation effect provides a potential treatment for improving motivation in clinics.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
汉堡包应助舒服的觅夏采纳,获得10
2秒前
suicone完成签到,获得积分10
9秒前
zqq完成签到,获得积分0
17秒前
19秒前
归陌完成签到 ,获得积分10
19秒前
44秒前
mmyhn发布了新的文献求助10
48秒前
1分钟前
Dave发布了新的文献求助10
1分钟前
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
1分钟前
wbs13521完成签到,获得积分0
1分钟前
2分钟前
儒雅致远发布了新的文献求助10
2分钟前
2分钟前
Hello应助儒雅致远采纳,获得10
2分钟前
正在获取昵称中...完成签到,获得积分10
2分钟前
2分钟前
爆米花应助xiongdi521采纳,获得10
2分钟前
3分钟前
xiongdi521发布了新的文献求助10
3分钟前
xiongdi521完成签到,获得积分10
3分钟前
mmyhn发布了新的文献求助10
3分钟前
3分钟前
4分钟前
Liiiiiiiiii发布了新的文献求助10
4分钟前
三水完成签到 ,获得积分20
4分钟前
小净完成签到 ,获得积分20
4分钟前
cccttt完成签到,获得积分10
4分钟前
mmyhn发布了新的文献求助10
4分钟前
Echo完成签到,获得积分10
4分钟前
无花果应助zzx采纳,获得10
4分钟前
可爱的香菇完成签到 ,获得积分10
4分钟前
5分钟前
dovejingling完成签到,获得积分10
5分钟前
lulu发布了新的文献求助20
5分钟前
Jasper应助科研通管家采纳,获得10
5分钟前
顾矜应助科研通管家采纳,获得10
5分钟前
5分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990045
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256354
捐赠科研通 3270943
什么是DOI,文献DOI怎么找? 1805146
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228