Integrating metabolomics and network pharmacology to evaluate the effectiveness of traditional medicinal parts of Chinese herbal medicine Cassia agnes Brenan

卡西亚 传统医学 中医药 医学 药理学 替代医学 病理
作者
Qin Liu,Katherine Tan,Yi Liu,Xiao‐Han Tang,Weiqiong Li,Jiaqi He,Yafang Li,Tao Li,Minggao Zi,Hongyan Yang,Yuyi Chai
出处
期刊:South African Journal of Botany [Elsevier BV]
卷期号:170: 137-144
标识
DOI:10.1016/j.sajb.2024.05.020
摘要

Cassia agnes Brenan, a classic Chinese herbal formula, has been widely used for treating various ailments such as stomach pain, cold, malaria, measles, chicken pox, and constipation. Modern pharmacological studies have shown that different parts of Cassia agnes Brenan have distinct effects. However, there is a lack of literature on the comparative analysis of chemical components across different parts. The aim of this study is to identify the distinct compounds present in Cassia agnes Brenan leaves and fruits and to conduct network pharmacological research on these compounds to identify potential active ingredients. Metabolomics was employed to analyze the chemical composition of various parts of Cassia agnes Brenan. Subsequently, network pharmacological research was conducted to identify potential active compounds. Target prediction and KEGG pathway analysis were performed to analyze the pharmacological effects and mechanisms of Cassia agnes Brenan. Flavonoids were found to be significantly enriched in the leaves compared to the fruits, suggesting that leaves may be the primary medicinal part of Cassia agnes Brenan. Additionally, an effective and rapid method for evaluating the efficacy of traditional medicinal parts of Chinese herbal medicine was established. In this study, we identified potential active compounds in different parts of Cassia agnes Brenan and provided a rapid method for evaluating the efficacy of traditional medicinal parts of Chinese herbal medicine. These findings contribute to the understanding of the pharmacological effects and mechanisms of Cassia agnes Brenan, facilitating further research in this area.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
南风完成签到,获得积分10
刚刚
专注凝蝶发布了新的文献求助10
1秒前
害羞洋葱完成签到,获得积分20
1秒前
1秒前
aaron9898完成签到,获得积分10
1秒前
公冶嘉懿发布了新的文献求助10
1秒前
认真的小懒虫完成签到,获得积分10
2秒前
叶子发布了新的文献求助30
2秒前
ayuelei发布了新的文献求助10
2秒前
2秒前
共享精神应助叶子j945采纳,获得10
2秒前
南风发布了新的文献求助30
4秒前
4秒前
5秒前
Orange应助大佬虎采纳,获得30
5秒前
自觉的傲薇应助行走的鱼采纳,获得20
6秒前
扎心发布了新的文献求助10
6秒前
9527完成签到,获得积分10
6秒前
wildeager完成签到,获得积分10
6秒前
6秒前
皮雁子发布了新的文献求助10
6秒前
脑洞疼应助ddd采纳,获得10
6秒前
研友_pnxAJZ发布了新的文献求助10
7秒前
天天快乐应助白筠233采纳,获得10
7秒前
7秒前
7秒前
今后应助包子采纳,获得10
7秒前
8秒前
Ava应助害羞洋葱采纳,获得10
8秒前
9秒前
ccc完成签到 ,获得积分10
9秒前
1233330完成签到,获得积分10
9秒前
学阀发布了新的文献求助10
9秒前
10秒前
七七完成签到 ,获得积分10
10秒前
10秒前
shuangshine7完成签到,获得积分10
11秒前
11秒前
lin应助AJ采纳,获得10
11秒前
11秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969335
求助须知:如何正确求助?哪些是违规求助? 3514162
关于积分的说明 11172430
捐赠科研通 3249456
什么是DOI,文献DOI怎么找? 1794853
邀请新用户注册赠送积分活动 875437
科研通“疑难数据库(出版商)”最低求助积分说明 804809