化学
溶酶体
荧光
分辨率(逻辑)
生物物理学
纳米技术
光化学
生物化学
光学
酶
物理
材料科学
人工智能
计算机科学
生物
作者
Hongyong Zheng,Weikang Peng,Miaomiao Liu,Shusheng Zhang,Xiangzhi Song,Lei Yang
标识
DOI:10.1021/acs.analchem.4c02435
摘要
Ferroptosis is an iron-dependent programmed cell death that is characterized by the dysregulation of lipid reactive oxygen species (ROS) production, causing abnormal changes in hypochlorous acid (HClO) levels in lysosomes. Super-resolution imaging can observe the fine structure of the lysosome at the nanometer level; therefore, it can be used to detect lysosome HClO levels during ferroptosis at the suborganelle level. Herein, we utilize a ratiometric fluorescent probe,
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