粒体自噬
线粒体
生物发生
线粒体生物发生
生物
功能(生物学)
机制(生物学)
细胞生物学
神经科学
细胞器
计算生物学
自噬
遗传学
基因
细胞凋亡
哲学
认识论
作者
Bohao Liu,Chen-Zhen Xu,Yi Liu,Zilong Lu,Ting-Lv Fu,Guorui Li,Yu Deng,Guoqing Luo,Song Ding,Ning Li,Qing Geng
标识
DOI:10.1186/s40779-024-00536-5
摘要
Abstract Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable in vital life processes such as cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, a sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key processes like mitochondrial biogenesis, mitochondrial dynamics, and mitophagy, which have garnered increasing attention from researchers to unveil their specific molecular mechanisms. In this review, we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC. Furthermore, the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail. We also discuss agonists or antagonists targeting MQC, aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function.
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