再生医学
系统回顾
医学
生物信息学
生物
梅德林
计算生物学
干细胞
遗传学
生物化学
作者
Adolfo Rodríguez‐Eguren,Clara Bueno‐Fernandez,María Gómez‐Álvarez,Emilio Francés‐Herrero,António Pellicer,José Bellver,Emre Seli,Irene Cervelló
出处
期刊:Human Reproduction Update
[Oxford University Press]
日期:2024-05-25
被引量:4
标识
DOI:10.1093/humupd/dmae013
摘要
The establishment and maintenance of pregnancy depend on endometrial competence. Asherman syndrome (AS) and intrauterine adhesions (IUA), or endometrial atrophy (EA) and thin endometrium (TE), can either originate autonomously or arise as a result from conditions (i.e. endometritis or congenital hypoplasia), or medical interventions (e.g. surgeries, hormonal therapies, uterine curettage or radiotherapy). Affected patients may present an altered or inadequate endometrial lining that hinders embryo implantation and increases the risk of poor pregnancy outcomes and miscarriage. In humans, AS/IUA and EA/TE are mainly treated with surgeries or pharmacotherapy, however the reported efficacy of these therapeutic approaches remains unclear. Thus, novel regenerative techniques utilizing stem cells, growth factors, or tissue engineering have emerged to improve reproductive outcomes.
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