再生医学
再现性
生化工程
工程伦理学
风险分析(工程)
计算机科学
生物技术
医学
生物
干细胞
工程类
化学
细胞生物学
色谱法
作者
Alicia D. Henn,Kunal Mitra,Joshua Hunsberger,Xiuzhi Susan Sun,Mark Nardone,Ramon B. Montero,Sita Somara,Gary Green,A. Blanchard,Yu Shrike Zhang,Carl G. Simon,Randy Yerden
标识
DOI:10.1007/s40778-022-00219-8
摘要
Cell and tissue products do not just reflect their present conditions; they are the culmination of all they have encountered over time. Currently, routine cell culture practices subject cell and tissue products to highly variable and non-physiologic conditions. This article defines five cytocentric principles that place the conditions for cells at the core of what we do for better reproducibility in Regenerative Medicine.There is a rising awareness of the cell environment as a neglected, but critical variable. Recent publications have called for controlling culture conditions for better, more reproducible cell products.Every industry has basic quality principles for reproducibility. Cytocentric principles focus on the fundamental needs of cells: protection from contamination, physiologic simulation, and full-time conditions for cultures that are optimal, individualized, and dynamic. Here, we outline the physiologic needs, the technologies, the education, and the regulatory support for the cytocentric principles in regenerative medicine.
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