Peroxidase-like Nanozyme Composite-based Colorimetric Determination of Glutathione and Cysteine

化学 谷胱甘肽 生物分析 半胱氨酸 组合化学 生物传感器 纳米技术 色谱法 生物化学 材料科学
作者
Wengan Zhang,Binjie Chen,Ruke Wang,Jing Liu,Bo Wang
出处
期刊:Analytical Letters [Informa]
卷期号:57 (8): 1271-1281 被引量:2
标识
DOI:10.1080/00032719.2023.2245509
摘要

AbstractSimple, low-cost, and fast determination of cysteine and glutathione with high sensitivity is an essential problem to evaluate the physiological processes in living organisms. Artificial nanozymes have provided considerable opportunities in biosensing. In this work, using a graphene-based ternary nanozyme, we present a simple but efficient colorimetric method for the determination of cysteine and glutathione. The nanozyme exhibits excellent and stable catalytic performance toward H2O2 and catalyzes the 3,3′,5,5′-tetramethylbenzidine chromogenic reaction. However, this reaction is significantly suppressed by cysteine and glutathione. Thus, a sensitive colorimetric method is presented based upon this inhibition. Excellent performance with low detection limits, good selectivity, and rapid analysis suggests potential bioanalytical applications for the determination of cysteine and glutathione.Keywords: Biosensorcolorimetrycysteineglutathionereduced graphene oxide@hemin@gold nanoflower nanozymespectrophotometry Author contributionsConceptualization, Wengan Zhang; Data curation, Wengan Zhang; Funding acquisition, Jing Liu and Bo Wang; Investigation, Binjie Chen and Ruke Wang; Methodology, Wengan Zhang; Project administration, Jing Liu and Bo Wang; Supervision, Jing Liu and Bo Wang; Writing-original draft, Wengan Zhang; Writing-review & editing, Binjie Chen, Ruke Wang, Jing Liu and Bo Wang.Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThis research was funded by Shandong Key Laboratory of Biochemical Analysis (SKLBA2204) and the Shandong University of Science and Technology.
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