癌相关成纤维细胞
肿瘤微环境
结直肠癌
细胞外基质
免疫系统
癌症研究
转移
癌症
医学
免疫
肿瘤促进
肿瘤进展
生物
免疫学
癌变
内科学
细胞生物学
作者
Hiroaki Kasashima,Yasuhiro Fukui,Kisyu Kitayama,Yuichiro Miki,Mami Yoshii,Tatsunari Fukuoka,Tatsuro Tamura,Masatsune Shibutani,Takahiro Toyokawa,Shigeru Ree,Hiroaki Tanaka,Masakazu Yashiro,Kiyoshi Maeda
出处
期刊:PubMed
日期:2023-09-01
卷期号:50 (9): 958-959
摘要
Cancer-associated fibroblasts(CAFs)remodel the extracellular matrix(ECM)and shape the tumor microenvironment (TME), resulting in immune escape and the promotion of tumor metastasis. Using an orthotopic tumor model of colorectal cancers(CRCs)in mice, we demonstrated that the single-cell RNA sequencing of orthotopic rectal tumors identified a subpopulation of CAFs that modulate the immune response. In this review, we report that understanding the role of CAFs in the TME concerning tumor immunity may lead to future avenues for CAF-targeted therapy.
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