The associations of erythrocyte membrane polyunsaturated fatty acids with skeletal muscle loss: A prospective cohort study

多不饱和脂肪酸 医学 骨骼肌 人口 内科学 亚油酸 内分泌学 体质指数 脂肪酸 生物化学 化学 环境卫生
作者
Mengyang Su,Xuanrui Zhang,Wei Hu,Zhenxiao Yang,Danyu Chen,Yingdi Yang,Keliang Xie,Yu‐Ming Chen,Zheqing Zhang
出处
期刊:Clinical Nutrition [Elsevier BV]
卷期号:42 (12): 2328-2337 被引量:2
标识
DOI:10.1016/j.clnu.2023.09.027
摘要

Polyunsaturated fatty acids (PUFAs) may play a vital role in maintaining skeletal muscle mass in the aged population. This study investigated the longitudinal relationship between the concentrations of erythrocyte membrane PUFAs and age-related changes in skeletal muscle mass over an average 6.5 years of follow-up in a Chinese middle-aged and older adult population.A total of 1494 participants aged 57.4 ± 4.7 years were included in this study. Skeletal muscle mass was determined using dual-energy X-ray absorptiometry. Per year percent changes in the skeletal muscle index (Δ% SMI), appendicular skeletal muscle index (Δ% ASMI), and total body lean mass index (Δ% TBLMI) from baseline were calculated. Concentrations of total and individual cis-n-3 and cis-n-6 PUFAs of the erythrocyte membrane were determined using gas-liquid chromatography.Fully adjusted linear regression models showed that per unit increases in the concentrations of C18:2 n-6, C20:4 n-6, C22:4 n-6, and total n-6 PUFAs resulted in increases of 0.022%-0.155 % in the Δ% SMI (P for linearity: <0.001-0.006). Restricted cubic spline analysis revealed an inverted U-shaped relationship between the concentrations of C20:2 n-6, C22:5 n-3, C22:6 n-3, and total n-3 PUFAs and the Δ% SMI (P for non-linearity: <0.001-0.036). In addition, an inverted U-shaped curve was also detected for the relationships of the linoleic acid/α-linolenic acid ratio (P for non-linearity = 0.010) and n-6/n-3 PUFA ratio (P for non-linearity = 0.013) with the Δ% SMI, with the Δ% SMI peaking at respective ratios of 124.96 and 3.69. Similar associations were revealed by the Bayesian kernel machine regression model. No interaction effect was detected between the individual PUFAs for the Δ% SMI in the bivariate exposure-response analysis. Overall, similar results were observed for the Δ% ASMI and Δ% TBLMI.The associations between different individual PUFAs and age-related muscle loss in middle-aged and older adults may be different. Our results suggest that high concentrations of erythrocyte membrane n-6 PUFAs may be correlated with less skeletal muscle mass loss, whereas extremely high concentrations of n-3 PUFAs may be correlated with more muscle loss.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
CodeCraft应助大橙子采纳,获得10
1秒前
量子星尘发布了新的文献求助10
2秒前
jeeya完成签到,获得积分10
3秒前
5秒前
科目三应助科研通管家采纳,获得10
5秒前
科目三应助科研通管家采纳,获得10
5秒前
伦语发布了新的文献求助10
5秒前
顾矜应助科研通管家采纳,获得10
5秒前
xuzj应助科研通管家采纳,获得10
5秒前
xuzj应助科研通管家采纳,获得10
5秒前
5秒前
NexusExplorer应助科研通管家采纳,获得10
5秒前
5秒前
5秒前
丘比特应助科研通管家采纳,获得10
6秒前
yull完成签到,获得积分10
6秒前
小巧书雪完成签到,获得积分10
9秒前
大大怪将军完成签到,获得积分10
10秒前
哈哈哈完成签到 ,获得积分0
10秒前
小怪完成签到,获得积分10
11秒前
爱吃泡芙完成签到,获得积分10
12秒前
白桃战士完成签到,获得积分10
13秒前
15秒前
qingchenwuhou完成签到 ,获得积分10
15秒前
XXX完成签到,获得积分10
16秒前
锡嘻完成签到 ,获得积分10
16秒前
17秒前
彗星入梦完成签到 ,获得积分10
17秒前
恋恋青葡萄完成签到,获得积分10
17秒前
隐形万言完成签到,获得积分10
19秒前
Time完成签到,获得积分10
19秒前
土木研学僧完成签到,获得积分10
20秒前
yjy完成签到 ,获得积分10
20秒前
A溶大美噶完成签到,获得积分10
20秒前
yar应助萨尔莫斯采纳,获得10
21秒前
Will发布了新的文献求助10
21秒前
美好的鹏笑完成签到,获得积分10
23秒前
啦啦啦啦啦完成签到,获得积分10
23秒前
LYegoist完成签到,获得积分10
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022