The ELOVL6 homolog in Penaeus vannamei plays a dual role in fatty acid metabolism and immune response

生物 甾醇调节元件结合蛋白 对虾 基因 打开阅读框 副溶血性弧菌 免疫系统 脂肪酸 生物化学 先天免疫系统 小虾 微生物学 基因表达 肽序列 细菌 遗传学 渔业
作者
Yuqing Zhou,Jude Juventus Aweya,Zishu Huang,Huiling Chen,Ziqiang Tang,Zhongxun Shi,Zhaohui Zheng,Yueling Zhang
出处
期刊:Molecular Immunology [Elsevier BV]
卷期号:164: 7-16
标识
DOI:10.1016/j.molimm.2023.10.008
摘要

In mammals, elongation of very long chain fatty acid protein 6 (ELOVL6), a key enzyme in long chain fatty acids elongation, has been reported to regulate other metabolism processes and immunity, including inflammation in vertebrates. However, little is currently known about the ELOVL6 homolog in invertebrates, especially its role in immune response. In this study, the ELOVL6 ortholog in Penaeus vannamei (designated PvELOVL6) was cloned and found to have an open reading frame (ORF) of 435 bp and encode a putative protein of 144 amino acids. Transcripts of PvELOVL6 are constitutively expressed in all shrimp tissues tested and induced in the hepatopancreas and hemocytes by Vibrio parahaemolyticus and Streptococcus iniae. Besides, PvELOVL6 knockdown followed by Vibrio parahaemolyticus challenge revealed that PvELOVL6 regulates the expression of several genes involved in fatty acid metabolism and immunity, including PvLGBP, PvLectin, PvMnSOD, PvProPO, PvFABP, PvLipase, PvCOX and PvGPDH. Moreover, transcript levels of PvELOVL6, fatty acids metabolism-related genes (i.e., PvGPDH, PvFABP, PvPERO and PvSPLA2), and immune-related genes (i.e., PvProPO, PvLectin, PvLGBP, PvLysozyme and PvCatalase) increased after silencing of the sterol regulatory element binding protein (PvSREBP). Thus, PvELOVL6 is involved in immune response and regulated by PvSREBP through an unknown mechanism in penaeid shrimp.

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