神经黑素
黑质
双相情感障碍
磁共振成像
核医学
接收机工作特性
曲线下面积
内科学
萧条(经济学)
置信区间
核磁共振
医学
化学
病理
心理学
内分泌学
多巴胺
放射科
锂(药物)
多巴胺能
物理
宏观经济学
经济
作者
Xinping Kuai,Dandan Shao,Shengyu Wang,Pu‐Yeh Wu,Yan Wu,Xuexue Wang
标识
DOI:10.1093/cercor/bhad423
摘要
Abstract Depression in bipolar disorder (BD-II) is frequently misdiagnosed as unipolar depression (UD) leading to inappropriate treatment and downstream complications for many bipolar sufferers. In this study, we evaluated whether neuromelanin-MR signal and volume changes in the substantia nigra (SN) can be used as potential biomarkers to differentiate BD-II from UD. The signal intensities and volumes of the SN regions were measured, and contrast-to-noise ratio (CNR) to the decussation of the superior cerebellar peduncles were calculated and compared between healthy controls (HC), BD-II and UD subjects. Results showed that compare to HC, both BD-II and UD subjects had significantly decreased CNR and increased volume on the right and left sides. Moreover, the volume in BD-II group was significantly increased compared to UD group. The area under the receiver operating characteristic curve (AUC) for discriminating BD from HC was the largest for the Volume-L (AUC, 0.85; 95% confidence interval [CI]: 0.77, 0.93). The AUC for discriminating UD from HC was the largest for the Volume-L (AUC, 0.76; 95% CI: 0.65, 0.86). Furthermore, the AUC for discriminating BD from UD was the largest for the Volume-R (AUC, 0.73; 95% CI: 0.62, 0.84). Our findings suggest that neuromelanin-sensitive magnetic resonance imaging techniques can be used to differentiate BD-II from UD.
科研通智能强力驱动
Strongly Powered by AbleSci AI