P13.01.A POST-OPERATIVE MRI SYNTHESIS FROM PRE-OPERATIVE MRI AND POST-OPERATIVE CT USING CONDITIONAL GAN FOR THE ASSESSMENT OF DEGREE OF RESECTION

Abstract BACKGROUND Magnetic resonance imaging (MRI) is an essential part of assessing the extension of resection after craniotomy, allowing for accurate assessment of the brain. However, the application of MRI within 72 hours after surgery is limited, owing to its high cost, long time duration, and patients’ limited mobility. Besides, MRI excludes people with contraindications, including implantable electronic devices or artificial limbs, in which sceneries computerized tomography (CT) is the only available choice. To overcome these limitations, we investigated the use of a deep learning model for synthesizing post-operative MRI images. MATERIAL AND METHODS We aim to employ Cross-domain Correspondence Learning for Exemplar-based Image Translation Network (CoCosNet), an exemplar-based image translation model to synthesize T1 contrast-enhanced (T1ce) MRI images by combining post-operative T1ce and post-operative CT images. 233 cases were retrospectively collected at Sun Yat-sen University Cancer Center, who underwent complete MRI and CT scans. RESULTS After 200 epochs and a batch size of 10, CoCosNet achieved comparable results compared to other existing models, with objective indicators structural similarity index = 0.75, peak signal-to-noise ratio = 21.68, and mean absolute error = 0.007. Furthermore, assessments of the extent of resection between the true and synthesized T1ce images achieve great consistency. CONCLUSION Our study demonstrates the effectiveness of the CoCosNet deep learning model in synthesizing post-operative MRI images from pre-operative MRI and post-operative CT scans. Our quantitative analysis indicates that the synthesized images have comparable quality to real MRI images and are able to accurately assess the extent of resection. This approach has a promising future by providing a reliable alternative to traditional post-operative MRI.