化学
纳米载体
阳离子脂质体
阳离子聚合
基因传递
脂质体
核酸
两亲性
Zeta电位
组合化学
纳米技术
生物物理学
纳米颗粒
基因
药物输送
遗传增强
有机化学
生物化学
聚合物
生物
材料科学
共聚物
作者
Zhou Chena,Aili Zhang,Zhaogang Yang,Xinmei Wang,Lingqian Chang,Zhaofeng Chen,Ly James Lee
标识
DOI:10.2174/1385272820666160202004348
摘要
With the development of nanotechnology, nano-biomaterials have shown good development prospects in gene therapy. Cationic lipids include a group of amphiphiles that exhibit positive charge which interacts with negatively charged DNA/RNA leading to the formation of complexes containing condensed gene materials. Cationic liposomes complexed with gene materials are promising non-viral carriers for gene therapy. As an environmentally ionized cationic lipid, N-[1-(2,3-dioleyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTMA) shows positive charge at low pH with moderate pKa value due to the headgroup of tertiary amine. It makes 1,2-dioleyloxy-N,N-dimethyl-3- aminopropane (DODMA) very effective in encapsulating nucleic acids during synthesis by temporarily reducing pH. Thus, lipid nanoparticles with DODMA can have neutral or low zeta potential at physiological pH. These remarkable structure-dependent properties have far reaching application potential in gene therapy. This review summarizes the synthesis methods and structure characteristics of DODMA and derivatives, and illustrates their applications in gene delivery. Keywords: DODMA, cationic lipid, liposome, gene delivery.
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