化学
发色团
丁酸
氨基酸
吸收(声学)
苯乙酸
激发态
立体化学
核苷酸
谷氨酸
辐照
药物化学
光化学
有机化学
生物化学
核物理学
声学
物理
基因
作者
Peter G. Conrad,Richard S. Givens,Jörg F. Weber,Karl Kandler
出处
期刊:Organic Letters
[American Chemical Society]
日期:2000-05-10
卷期号:2 (11): 1545-1547
被引量:76
摘要
Introducing 3-methoxy or 3,5-dimethoxy substituents on the 4-hydroxyphenacyl (pHP) photoremovable protecting group has been explored with two excitatory γ-amino acids, l-glutamic acid and γ-amino butyric acid (GABA). These substituents significantly extend the absorption range of the pHP chromophore, e.g., the tail of absorption bands of 2a,b extend above 400 nm, well beyond the absorptions of aromatic amino acids and nucleotides. Irradiation releases the amino acids with rate constants of ∼107 s-1 and appearance efficiencies (Φapp) of 0.03−0.04. The photoproducts are formed through the pHP excited triplet and are primarily products of photoreduction and photohydrolysis. 1a,b also rearranged to the phenylacetic acid 3.
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