格式化
同化(音韵学)
甲酸脱氢酶
化学
生化工程
代谢途径
合成生物学
生物化学
生物
计算生物学
酶
语言学
工程类
哲学
催化作用
出处
期刊:Biochemistry
[American Chemical Society]
日期:2016-07-05
卷期号:55 (28): 3851-3863
被引量:118
标识
DOI:10.1021/acs.biochem.6b00495
摘要
Formate may become an ideal mediator between the physicochemical and biological realms, as it can be produced efficiently from multiple available sources, such as electricity and biomass, and serve as one of the simplest organic compounds for providing both carbon and energy to living cells. However, limiting the realization of formate as a microbial feedstock is the low diversity of formate-fixing enzymes and thereby the small number of naturally occurring formate-assimilation pathways. Here, the natural enzymes and pathways supporting formate assimilation are presented and discussed together with proposed synthetic routes that could permit growth on formate via existing as well as novel formate-fixing reactions. By considering such synthetic routes, the diversity of metabolic solutions for formate assimilation can be expanded dramatically, such that different host organisms, cultivation conditions, and desired products could be matched with the most suitable pathway. Astute application of old and new formate-assimilation pathways may thus become a cornerstone in the development of sustainable strategies for microbial production of value-added chemicals.
科研通智能强力驱动
Strongly Powered by AbleSci AI