淋巴瘤
流式细胞术
顺铂
癌症研究
化疗
BCL10
细胞凋亡
免疫组织化学
细胞生长
细胞
T细胞淋巴瘤
生物
医学
免疫学
内科学
遗传学
生物化学
作者
Yi Li,Jing Wang,Xiaoyan Ke
出处
期刊:PubMed
日期:2013-04-01
卷期号:21 (2): 366-70
被引量:3
标识
DOI:10.7534/j.issn.1009-2137.2013.02.022
摘要
In order to investigate the effect of PD-L1 on lymphoma cell proliferation and chemotherapy resistance, and explore a new and promising approach for therapy of lymphomas. The level of PD-L1 expression in tissues of patients with lymphoma and cell lines were detected by immunohistochemistry and flow cytometry. Both the stable high-PDL1-A20 cell strain and low-PDL1-A20 cell strain were sorted by flow cytometry, then inoculated into BALB/c mice as to establish a lymphoma bearing mouse model for observing tumor genesis. Finally, the effect of PD-L1 on routinely chemotherapy drug-cisplatin were observed. The results showed that the PD-L1 highly and widely expressed in lymphoma tissue and cell strains, the stable high-PD-L1 cell strain sorted by flow cytometry have higher lymphoma genesis than that of low-PD-L1 cell strain. It is concluded that PD-L1 can promote lymphoma genesis, meanwhile the PD-L1 may resist effect of cisplatin on lymphoma cells through anti-apoptosis.
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