蒙特利尔认知评估
切断
假阳性悖论
认知
荟萃分析
尤登J统计
医学
心理学
认知障碍
接收机工作特性
内科学
统计
精神科
数学
量子力学
物理
作者
Nicole Carson,Larry Leach,Kelly J. Murphy
摘要
Objective The Montreal Cognitive Assessment (MoCA; Nasreddine et al. , 2005) is a cognitive screening tool that aims to differentiate healthy cognitive aging from Mild Cognitive Impairment (MCI). Several validation studies have been conducted on the MoCA, in a variety of clinical populations. Some studies have indicated that the originally suggested cutoff score of 26/30 leads to an inflated rate of false positives, particularly for those of older age and/or lower education. We conducted a systematic review and meta‐analysis of the literature to determine the diagnostic accuracy of the MoCA for differentiating healthy cognitive aging from possible MCI. Methods Of the 304 studies identified, nine met inclusion criteria for the meta‐analysis. These studies were assessed across a range of cutoff scores to determine the respective sensitivities, specificities, positive and negative predictive accuracies, likelihood ratios for positive and negative results, classification accuracies, and Youden indices. Results Meta‐analysis revealed a cutoff score of 23/30 yielded the best diagnostic accuracy across a range of parameters. Conclusions A MoCA cutoff score of 23, rather than the initially recommended score of 26, lowers the false positive rate and shows overall better diagnostic accuracy. We recommend the use of this cutoff score going forward. Copyright © 2017 John Wiley & Sons, Ltd.
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