COPD exacerbations significantly impact quality of life as measured by SGRQ-C total score: results from the FLAME study

医学 恶化 慢性阻塞性肺病 沙美特罗 生活质量(医疗保健) 内科学 慢性阻塞性肺病加重期 茚达特罗 物理疗法 肺功能 慢性阻塞性肺疾病急性加重期 护理部
作者
Nicolás Roche,Jadwiga A. Wedzicha,Francesco Patalano,Stefan Frent,Michael Larbig,Steven S. Shen,Robert Fogel,Donald Banerji
标识
DOI:10.1183/1393003.congress-2017.oa1487
摘要

Introduction: Exacerbations are a major driver of impaired health-related quality of life (HRQoL) in patients with COPD.1 Indacaterol/glycopyrronium significantly reduced annualised rate of all and moderate/severe exacerbations versus salmeterol/fluticasone in the 52-week FLAME study.2 We assessed the impact of occurrence of COPD exacerbation on HRQoL in COPD patients from the FLAME study. Methods: Adjusted SGRQ-C total scores were compared in patients with 0 and ≥1 exacerbations since the last visit, on Days 29, 85, 183, 267 and 365, from the FLAME study. Improvement in SGRQ-C total score was also evaluated for percentage of COPD exacerbation-free days since the last visit. Results: There was a significant difference in adjusted SGRQ-C total score in patients without an exacerbation and those with ≥1 exacerbations since the last visit (Table), with a greater negative impact on HRQoL related to moderate/severe exacerbations. Significantly greater improvement (P < 0.001) in SGRQ-C score was observed with higher percentage of COPD exacerbation-free days since the last visit. Conclusion: The occurrence of COPD exacerbation is significantly associated with impairment in health-related quality of life. A greater impact was noted for moderate/severe exacerbations. References 1. Wedzicha JA, et al. BMC Med 2013;11:181 2. Wedzicha JA, et al. N Engl J Med 2016;374(23):2222–2234

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