自愈水凝胶
生物相容性
DNA
聚合
纳米团簇
材料科学
纳米技术
荧光
生物传感器
生物分子
聚合物
化学
高分子化学
生物化学
复合材料
物理
冶金
量子力学
作者
Jinhui Geng,Chi Yao,Xiaohong Kou,Jianpu Tang,Dan Luo,Dayong Yang
标识
DOI:10.1002/adhm.201700998
摘要
Abstract DNA has arisen as a promising building material for the construction of hydrogels owing to its unique properties such as designability and biocompatibility. All‐DNA hydrogels with only DNA molecules may have limited applications; hence a composite DNA hydrogel with multifunctional moieties is highly desired to cater for specific applications. Herein, a multifunctional DNA hydrogel is created by incorporating DNA with silver nanoclusters (AgNCs), in which AgNCs render the hydrogel simultaneously with fluorescent and antibacterial functions. A circular DNA is rationally designed, which allows for the elongation of DNA chain via an enzymatic polymerization as well as the formation of AgNCs onto DNA scaffolds. The resultant hybrid DNA hydrogel not only shows distinctive morphology and mechanical properties, but also exhibits fluorescent and antibacterial functions. These characteristics, along with its biocompatibility, will allow the hydrogel to be suitable for a variety of potential biomedical applications such as tissue engineering, wound dressing, biosensing, and bioimaging.
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