线粒体
免疫系统
细胞生物学
生物
细胞代谢
信号
细胞器
细胞命运测定
细胞
生物能学
免疫学
基因
生物化学
转录因子
作者
Manan Mehta,Samuel E. Weinberg,Navdeep S. Chandel
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2017-07-03
卷期号:17 (10): 608-620
被引量:314
摘要
Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically.
科研通智能强力驱动
Strongly Powered by AbleSci AI