Different Effects of Continuous and Intermittent Patterns of Growth Hormone Administration on Lipoprotein Levels inGrowth Hormone-Deficient Patients

医学 内科学 内分泌学 丸(消化) 肢端肥大症 脂蛋白(a) 生长激素 傍晚 激素 脂蛋白 胆固醇 物理 天文
作者
Torben Laursen,Lone Lemming,Jens Otto Lunde Jørgensen,Ib Christian Klausen,Jens Sandahl Christiansen
出处
期刊:Hormone Research in Paediatrics [S. Karger AG]
卷期号:50 (5): 284-291 被引量:17
标识
DOI:10.1159/000023292
摘要

<b>Background:</b> Lipoprotein (a) (Lp(a)) is a risk marker for the development of atherosclerotic coronary heart disease. Growth hormone (GH) administration to GH-deficient (GHD) adults increases serum Lp(a) concentrations, and the levels of Lp(a) and GH are correlated in patients with acromegaly. Studies in rats have demonstrated differential effects of constant and intermittent GH patterns on levels of certain lipoproteins. The aim of the present studies was to describe the impact of intermittent and continuous patterns of GH delivery to GHD patients on serum levels of Lp(a) and other lipoproteins. <b>Methods:</b> In one study (A) 10 GHD patients received in random order a fixed GH dose intravenously as: (1) continuous infusion; (2) eight bolus injections, and (3) a combination of 1 and 2. Each study lasted 36 h and was preceded by at least 4 weeks without GH. In another study (B) 13 GHD patients received GH in random order as: (1) continuous subcutaneous (s.c.) infusion, and (2) daily s.c. injections in the evening for 1 month each. The patients were studied during steady-state conditions at the end of each treatment period. <b>Results:</b> In study A Lp(a) levels increased significantly following continuous (p < 0.05) and combined patterns (p < 0.02) of GH administration to GH-deprived GHD patients, whereas the increase after GH bolus injections alone was not significant (p = 0.14). In study B significantly higher (p < 0.05) serum levels of Lp(a) were obtained after continuous s.c. infusion as compared with daily s.c. injections of GH. Concentrations of the high-density lipoprotein (HDL) cholesterol were significantly lower (p < 0.02) after the continuous GH pattern. Similarly, the HDL fraction Apo A-1 tended to be lower with constant GH delivery (p = 0.052). Serum levels of total cholesterol, triglyceride and Apo B were similar on the two occasions. <b>Conclusion:</b> Short-term GH administration to GH-deprived GHD patients increased serum Lp(a), but only significantly with continuous delivery. During more prolonged GH exposure, constant s.c. infusion of GH resulted in slightly raised Lp(a) levels and reduced HDL and Apo A1 levels as compared with intermittently administered GH. The findings are consistent with the more effective induction of serum IGF-I levels after continuous patterns of GH delivery previously reported in GHD patients. Longer-term data are needed before conclusions with respect to the impact of the pattern of GH administration on, e.g., the risk of developing coronary heart disease can be drawn.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
张军辉发布了新的文献求助10
3秒前
3秒前
wanglf发布了新的文献求助30
4秒前
悦耳的盼芙完成签到,获得积分10
4秒前
顾矜应助CC采纳,获得10
5秒前
Elijah完成签到,获得积分10
7秒前
声声慢完成签到 ,获得积分10
8秒前
9秒前
9秒前
9秒前
xiaoxin完成签到,获得积分20
10秒前
Owen应助懒羊羊大王采纳,获得10
12秒前
13秒前
Echizen完成签到,获得积分10
13秒前
14秒前
14秒前
一切随风完成签到,获得积分10
16秒前
开心完成签到,获得积分10
17秒前
xiaoxin发布了新的文献求助10
17秒前
18秒前
王艺霖发布了新的文献求助10
18秒前
在路上完成签到 ,获得积分10
18秒前
边渡有次子完成签到,获得积分10
21秒前
wanci应助老实的熊猫采纳,获得10
21秒前
默默的飞烟完成签到,获得积分10
22秒前
隐形鸣凤完成签到,获得积分10
25秒前
曲聋五完成签到 ,获得积分10
27秒前
嗯嗯嗯发布了新的文献求助10
27秒前
君子兰完成签到,获得积分10
28秒前
28秒前
我是老大应助lx33101128采纳,获得10
31秒前
小二郎应助白芷苏采纳,获得20
31秒前
33秒前
34秒前
Wt完成签到,获得积分20
34秒前
34秒前
打打应助强健的洋葱采纳,获得10
34秒前
34秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Development of general formulas for bolted flanges, by E.O. Waters [and others] 600
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3256413
求助须知:如何正确求助?哪些是违规求助? 2898688
关于积分的说明 8301838
捐赠科研通 2567805
什么是DOI,文献DOI怎么找? 1394718
科研通“疑难数据库(出版商)”最低求助积分说明 652913
邀请新用户注册赠送积分活动 630562