单倍群
生物
线粒体DNA
人线粒体DNA单倍型
进化生物学
谱系(遗传)
东亚
线粒体dna控制区
遗传学
中国
单倍型
基因
等位基因
地理
考古
作者
Qing‐Peng Kong,Chang Sun,Hua-Wei Wang,Mian Zhao,Wenzhi Wang,Zhong Li,Xiao-Dan Hao,Hui Pan,Shayan Wang,Yao-Ting Cheng,Chunling Zhu,Shi‐Fang Wu,Lina Liu,Jie-Qiong Jin,Yong‐Gang Yao,Ya‐Ping Zhang
标识
DOI:10.1093/molbev/msq219
摘要
In order to achieve a thorough coverage of the basal lineages in the Chinese matrilineal pool, we have sequenced the mitochondrial DNA (mtDNA) control region and partial coding region segments of 6,093 mtDNAs sampled from 84 populations across China. By comparing with the available complete mtDNA sequences, 194 of those mtDNAs could not be firmly assigned into the available haplogroups. Completely sequencing 51 representatives selected from these unclassified mtDNAs identified a number of novel lineages, including five novel basal haplogroups that directly emanate from the Eurasian founder nodes (M and N). No matrilineal contribution from the archaic hominid was observed. Subsequent analyses suggested that these newly identified basal lineages likely represent the genetic relics of modern humans initially peopling East Asia instead of being the results of gene flow from the neighboring regions. The observation that most of the newly recognized mtDNA lineages have already differentiated and show the highest genetic diversity in southern China provided additional evidence in support of the Southern Route peopling hypothesis of East Asians. Specifically, the enrichment of most of the basal lineages in southern China and their rather ancient ages in Late Pleistocene further suggested that this region was likely the genetic reservoir of modern humans after they entered East Asia.
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