免疫疗法
自然杀伤细胞
癌症免疫疗法
医学
过继性细胞移植
癌症
免疫学
细胞
离体
淋巴因子激活杀伤细胞
癌症研究
体内
T细胞
生物
免疫系统
白细胞介素21
细胞毒性
体外
内科学
生物技术
遗传学
作者
Tolga Sütlü,Evren Alici
标识
DOI:10.1111/j.1365-2796.2009.02121.x
摘要
Abstract. As our understanding of the molecular mechanisms governing natural killer (NK) cell activity increases, their potential in cancer immunotherapy is growing increasingly prominent. This review analyses the currently available preclinical and clinical data regarding NK cell‐based immunotherapeutic approaches in cancer starting from a historical background and an overview of molecular mechanisms taking part in NK cell responses. The status of NK cells in cancer patients, currently investigated clinical applications such as in vivo modulation of NK cell activity, ex vivo purification/expansion and adoptive transfer as well as future possibilities such as genetic modifications are discussed in detail.
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