Sirolimus: a new promising immunosuppressive drug. Towards a rationale for its use in renal transplantation

immunosuppressive drugs; rapamycin; renal IL4, in an autocrine or paracrine fashion.It also drives competent T-cell entry into the proliferation cycle via transplantation; sirolimus progression from the G1 to the S phase, with subsequent clonal expansion and the acquisition of T-cell effector functions.