亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Cerebral Edema in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis

医学 溶栓 脑水肿 改良兰金量表 水肿 中线偏移 冲程(发动机) 麻醉 缺血性中风 内科学 心脏病学 缺血 外科 计算机断层摄影术 心肌梗塞 工程类 机械工程
作者
Daniel Strbian,Atte Meretoja,Jukka Putaala,Markku Kaste,Turgut Tatlisumak
出处
期刊:International Journal of Stroke [SAGE Publishing]
卷期号:8 (7): 529-534 被引量:64
标识
DOI:10.1111/j.1747-4949.2012.00781.x
摘要

Background Cerebral edema (CED) deteriorates outcome of ischemic stroke patients, and there is no effective medical treatment. Limited data exist on cerebral edema after stroke thrombolysis. Aims We aimed to analyze impact of cerebral edema on the outcome of thrombolysis-treated patients. Methods Our cohort included 943 thrombolysis-treated ischemic stroke patients at the Helsinki University Central Hospital (1995–2008). Cerebral edema represented focal brain swelling up to 1/3 (CED-1) or greater than 1/3 (CED-2) of the hemisphere, or midline shift (CED-3). We studied baseline parameters associated with development of cerebral edema and association of cerebral edema with three-month outcome (modified Rankin Scale, mRS). Results On control imaging, CED-1 was present in 167 (17·7%), CED-2 in 40 (4·2%), and CED-3 in 53 (5·6%) patients. Compared with patients without edema ( n = 683), patients with cerebral edema had higher baseline National Institutes of Health Stroke Scale scores, more often hyperdense cerebral artery sign or early infarct signs on admission computerized tomography, and received thrombolysis later. Cerebral edema was independently associated with poor outcome (mRS 3–6) and mortality, whereas favorable outcome (mRS 0–2) was observed in 77 (46%), 5 (13%), and 3 (6%) patients with CED 1, 2, and 3, respectively. Anti-edema treatment was considered necessary and administered to 49/260 (19%) patients; only five had favorable outcome. Conclusions Cerebral edema is frequent (28%) among thrombolysis-treated ischemic stroke patients, occurring in severe forms in 10%. Higher baseline National Institutes of Health Stroke Scale, presence of hyperdense cerebral artery sign or early infarct signs, and longer treatment delays are associated with edema development. Edema is a strong independent predictor of three-month outcome. Effect of anti-edema treatment was modest.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wuran发布了新的文献求助10
刚刚
AiQi完成签到 ,获得积分10
7秒前
14秒前
博慧完成签到,获得积分10
15秒前
wanci应助ly采纳,获得10
17秒前
最最最发布了新的文献求助10
17秒前
24秒前
H_C发布了新的文献求助20
26秒前
利好完成签到 ,获得积分10
26秒前
29秒前
传奇3应助简单山水采纳,获得10
29秒前
和和和发布了新的文献求助10
31秒前
ly发布了新的文献求助10
32秒前
Wei完成签到 ,获得积分10
37秒前
稻子完成签到 ,获得积分10
39秒前
wanci应助ly采纳,获得10
46秒前
和和和完成签到,获得积分10
53秒前
小蘑菇应助iiii采纳,获得50
1分钟前
1分钟前
简单山水发布了新的文献求助10
1分钟前
1分钟前
灵感大王喵完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
iiii发布了新的文献求助50
1分钟前
爆米花应助拾光采纳,获得10
1分钟前
Percy完成签到 ,获得积分10
1分钟前
1分钟前
顾矜应助科研通管家采纳,获得10
1分钟前
英俊的铭应助简单山水采纳,获得10
1分钟前
1分钟前
鹿茸与共发布了新的文献求助10
1分钟前
SciGPT应助wuran采纳,获得10
1分钟前
2分钟前
2分钟前
充电宝应助仓鼠球采纳,获得10
2分钟前
拾光发布了新的文献求助10
2分钟前
wry完成签到,获得积分10
2分钟前
开心每一天完成签到 ,获得积分10
2分钟前
2分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990015
求助须知:如何正确求助?哪些是违规求助? 3532077
关于积分的说明 11256227
捐赠科研通 3270933
什么是DOI,文献DOI怎么找? 1805139
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228