生物
DNA甲基化
RNA导向的DNA甲基化
表观遗传学
转座因子
DNA
表观遗传学
遗传学
体育锻炼的表观遗传学
基因组印记
基因组
基因
基因表达
作者
Julie A. Law,Steven E. Jacobsen
摘要
Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological processes, including gene and transposon silencing, imprinting and X chromosome inactivation. Recent findings in plants and animals have greatly increased our understanding of the pathways used to accurately target, maintain and modify patterns of DNA methylation and have revealed unanticipated mechanistic similarities between these organisms. Key roles have emerged for small RNAs, proteins with domains that bind methylated DNA and DNA glycosylases in these processes. Drawing on insights from both plants and animals should deepen our understanding of the regulation and biological significance of DNA methylation.
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