维生素
化学
生物转化
维生素E
维生素C
维生素D与神经学
体内
抗坏血酸
生物化学
食品科学
离体
药理学
视黄醇
核黄素
抗氧化剂
人体皮肤
作者
W Baschong,C Artmann,D Hueglin,J Roeding
出处
期刊:Journal of Cosmetic Science
日期:2001-05-01
卷期号:52 (3): 155-161
被引量:33
摘要
For better stability, vitamin E is commonly used as the non-active esterified pro-drug. Such esters are postulated to be hydrolyzed to the free active form by skin-related esterases. So far, successful conversion of esterified vitamin E to free vitamin E (tocopherol) has been mainly delineated from observed biological effects. Quantitative evidence in human skin is poor. In vitro and in vivo studies on human and animal skin have proved ambiguous. Formulation-based effects may have added to this controversy. In the present study, comparable amounts of vitamin E acetate (i) in oil (Mygliol-812N), (ii) surfactant-solubilized in water, (iii) encapsulated in liposomes, or (iv) encapsulated in Nanotopes were applied to human skin mounted in modified Franz-perfusion chambers that permit emulation of both open or occlusive conditions. The distribution of vitamin E total (vitamin E acetate + vitamin E) was assessed on the skin surface, in the horny layers, and in the underlying skin by high-pressure liquid chromatography (HPLC), with a recovery higher than 90%. Vitamin E acetate in Mygliol deposited exclusively on the surface and in the stratum corneum. In contrast, solubilized or encapsulated vitamin E acetate deposited also in the underlying skin. Nanotopes performed best, followed by liposomes and solubilized vitamin E acetate. Non-occlusive application favored deposition in the skin relative to occlusive application. Conversion of vitamin E acetate to vitamin E was not observed on the skin surface or in the horny layers, while in the underlying skin up to 50% of the vitamin E total was deacetylated.
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