The subtemporal and preauricular infratemporal operative technique is an approach to the skull base through the anterior portion of the petrous temporal bone and is used for the removal of predominantly extradural tumors in this region. The present study, based on dissection of human cadavers, describes the use of this approach for the management of intradural lesions in the region of the clivus. Its main advantages include avoidance of brain retraction, the use of an extrapharyngeal route, and exposure of the ventral aspect of the pons and medulla and related structures caudal to the trigeminal root. This approach can easily be combined with an intradural subtemporal approach to provide additional exposure of the superior clivus rostral to the trigeminal root. Combining the two approaches provides direct access to the ventral surface of the entire brain stem from the dorsum sellae to the hypoglossal foramina. Five patients with lesions in the clivus and petrous apex have been operated on via this approach. Details of the anatomical aspects of the approach and its applications are presented.