表观遗传学
染色质重塑
染色质
组蛋白甲基化
组蛋白密码
生物
DNA甲基化
组蛋白
癌症表观遗传学
表观遗传学
组蛋白修饰酶
体育锻炼的表观遗传学
组蛋白甲基转移酶
细胞生物学
遗传学
DNA
基因
核小体
基因表达
作者
Theresa M. Geiman,Keith D. Robertson
摘要
Abstract DNA methylation is important in the control of gene transcription and chromatin structure. The complexities of this process are just beginning to be elucidated in relationship to other epigenetic mechanisms. Exciting new research in the areas of histone methylation and chromatin remodeling make it clear just how important the connections between these various mechanisms and DNA methylation are for the control of chromosome structure and gene expression. Emerging evidence suggests that chromatin remodeling enzymes and histone methylation are essential for proper DNA methylation patterns. Other histone modifications, such as acetylation and phosphorylation, in turn, affect histone methylation and histone methylation also appears to be highly reliant on chromatin remodeling enzymes. This review will summarize what is likely only the beginning of a flood of new information that will ultimately link all epigenetic modifications of the mammalian genome. A model will also be put forth to account for how chromatin modifications lead to genomic DNA methylation patterns. J. Cell. Biochem. 87: 117–125, 2002. Published 2002 Wiley‐Liss, Inc.
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