氧化应激
肌萎缩侧索硬化
活性氧
疾病
神经科学
抗氧化剂
医学
氧化磷酸化
药物发现
化学
生物信息学
生物
细胞生物学
生物化学
病理
作者
Kevin Barnham,Colin L. Masters,Ashley I. Bush
摘要
Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal-protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.
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