细胞凋亡
癌症研究
化疗
放射治疗
副作用(计算机科学)
癌症
医学
药理学
化学
癌细胞
癌症治疗
内科学
生物化学
计算机科学
程序设计语言
作者
Pavel G. Komarov,Elena A. Komarova,Roman V. Kondratov,Konstantin Christov-Tselkov,John S. Coon,Mikhail Chernov,Andrei V. Gudkov
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1999-09-10
卷期号:285 (5434): 1733-1737
被引量:1234
标识
DOI:10.1126/science.285.5434.1733
摘要
Chemotherapy and radiation therapy for cancer often have severe side effects that limit their efficacy. Because these effects are in part determined by p53-mediated apoptosis, temporary suppression of p53 has been suggested as a therapeutic strategy to prevent damage of normal tissues during treatment of p53-deficient tumors. To test this possibility, a small molecule was isolated for its ability to reversibly block p53-dependent transcriptional activation and apoptosis. This compound, pifithrin-α, protected mice from the lethal genotoxic stress associated with anticancer treatment without promoting the formation of tumors. Thus, inhibitors of p53 may be useful drugs for reducing the side effects of cancer therapy and other types of stress associated with p53 induction.
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