化学
水杨醛
席夫碱
化学计量学
卡拉胶
苯胺
消炎药
金属
钒
体内
核化学
药物化学
立体化学
无机化学
有机化学
药理学
生物化学
医学
生物技术
生物
作者
Shalini Shukla,Anju Mishra
标识
DOI:10.1016/j.arabjc.2014.08.020
摘要
The anti-inflammatory activity of the vanadium complexes has been studied using the carrageenan induced hind paw oedema method in albino rats (Wister strain). The coordination complexes of VO (II) with the Schiff base derived from 4-aminoacetophenone, 1-acetonaphthone and 4-methoxybenzaldehyde with 2-imino 4-thiobiuret; 3-acetoxypyridine with 2-amino 4-benzathiazol and 4-chloro aniline with salicylaldehyde have been synthesized and characterized by micro analytical data, FT-IR, electronic spectra and FAB-mass spectral studies. The Schiff base ligands behave as bidentated. The stoichiometry of the complexes is in 1:2 and 1:1 (M:L) ratio. The oxovanadium complexes in general show maximum inhibition percentage at about 1 h. After 1 h it goes on reducing and reaches a minimum at about 5 h. Complex-3 (91.17%) and Complex-5 (85.30%) are most potent in in vivo experiment and exhibited promising anti-inflammatory activity in 0.5 h.
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