生物
新生隐球菌
隐球菌
真菌病原
盖蒂隐球菌
真菌
病菌
机会性病原体
隐球菌病
微生物学
适应(眼睛)
基因
遗传学
毒力
神经科学
植物
作者
James W. Kronstad,Rodgoun Attarian,Brigitte Cadieux,Jaehyuk Choi,Cletus A. D’Souza,Emma Griffiths,Jennifer M. H. Geddes,Guanggan Hu,Won Hee Jung,Matthias Kretschmer,Sanjay Saikia,Joyce Wang
摘要
Cryptococcus neoformansis generally considered to be an opportunistic pathogen of immunocompromised individuals. However, as discussed here, this view has been challenged by recent evidence of specialized host–pathogen interactions, and by the emergence of the related speciesCryptococcus gattiias a primary pathogen of immunocompetent populations. Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen because of its tendency to infect immunocompromised individuals, particularly those infected with HIV. However, this view has been challenged by the recent discovery of specialized interactions between the fungus and its mammalian hosts, and by the emergence of the related species Cryptococcus gattii as a primary pathogen of immunocompetent populations. In this Review, we highlight features of cryptococcal pathogens that reveal their adaptation to the mammalian environment. These features include not only remarkably sophisticated interactions with phagocytic cells to promote intracellular survival, dissemination to the central nervous system and escape, but also surprising morphological and genomic adaptations such as the formation of polyploid giant cells in the lung.
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