A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone

THis paper is a report of studies of two patients with bronchogenic carcinoma in whom hyponatremia developed as the result of unexplained failure of renal sodium conservation. The data indicate that sustained inappropriate secretion of antidiuretic hormone was probably responsible for the disorder of sodium metabolism. The physiologic abnormality appears to be analogous to that which can be produced by the continuous administration of pitressin® and water to normal subjects .