肺结核
结核分枝杆菌
免疫学
免疫系统
免疫
获得性免疫系统
生物
病毒学
抗原
结核病疫苗
潜伏性肺结核
T细胞
CD8型
细胞免疫
先天免疫系统
效应器
牛分枝杆菌
医学
病理
作者
Luke D. Jasenosky,Thomas J. Scriba,Willem A. Hanekom,Anne E. Goldfeld
摘要
The adaptive immune response mediated by T cells is critical for control of Mycobacterium tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens and host T-cell responses that are required for an effective adaptive immune response to M. tuberculosis infection are yet to be defined. Here, we review recent findings on CD4(+) and CD8(+) T-cell responses to M. tuberculosis infection and examine the roles of distinct M. tuberculosis-specific T-cell subsets in control of de novo and latent M. tuberculosis infection, and in the evolution of T-cell immunity to M. tuberculosis in response to tuberculosis treatment. In addition, we discuss recent studies that elucidate aspects of M. tuberculosis-specific adaptive immunity during human immunodeficiency virus co-infection and summarize recent findings from vaccine trials that provide insight into effective adaptive immune responses to M. tuberculosis infection.
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