LBA1 Final analysis of the placebo-controlled randomised phase III IMpassion031 trial evaluating neoadjuvant atezolizumab (atezo) plus chemotherapy (CT) followed by open-label adjuvant atezo in patients (pts) with early-stage triple-negative breast cancer (eTNBC)

IMpassion031 met its primary objective, significantly improving pathological complete response (pCR) rate with atezo added to neoadjuvant CT in pts with eTNBC (58% vs 41% with CT alone in the intent-to-treat [ITT] population; 17% difference, 1-sided p=0.0044) [Mittendorf 2020]. Benefit from atezo was seen regardless of PD-L1 status.