Variants in CYP2J2 and CYP2C9 Contribute to Susceptibility of Lung Cancer

Background: Cytochrome P450 (CYP) enzymes are involved in the metabolism of xenobiotic and carcinogen. In the study, we evaluated the association of CYP2J2 and CYP2C9 variants with lung cancer. Method: Five polymorphisms in CYP2J2 and four polymorphisms in CYP2C9 were genotyped in 507 lung cancer patients and 505 controls with Agena MassARRAY platform. The linkage of variants with lung cancer risk was evaluated by odds ratio (OR) and 95% confidence interval (CI) in genetic models and haplotype analyses. objective: To elucidate the relationship between the CYP2J2 and CYP2C9 gene polymorphisms and lung cancer susceptibility, we have performed a case-control study.The results shown that these two genetic polymorphisms are associated with lung cancer risk. Results: We found that CYP2C9 rs1934967 alleles were associated with lung cancer risk (P < 0.05). In stratified analysis, rs2280274 (women, non-smoker, non-drinker and lymphatic metastasis), rs11207535 (non-smoker and non-drinker), rs10889159 (non-smoker and non-drinker) of CYP2J2, whereas rs1934967 (age ≤ 60m, BMI > 24, squamous carcinoma) of CYP2C9 decreased lung cancer risk (P < 0.05). In addition, the results of linkage disequilibrium (LD) analysis showed that rs2280274|rs4388726 - TG (with adjustment: P = 0.042) of CYP2J2 and rs10509679|rs1934967|rs1934968|rs9332220 – GTGG (without adjustment: P = 0.044) of CYP2C9 were linked with a significantly decreased lung cancer risk. Conclusion: Our results indicated genetic variants in CYP2J2 and CYP2C9 might contribute to the susceptibility of lung cancer in Chinese population. result: We found that CYP2C9 rs1934967 was significantly linked with lung cancer risk in allele (P = 0.045) and additive (P = 0.049) models. In stratified analysis, rs2280274 (women, non-smoker, non-drinker and lymphatic metastasis), rs11207535 (non-smoker and non-drinker), rs10889159 (non-smoker and non-drinker) of CYP2J2 and rs9332220 (smoker) of CYP2C9 significantly decreased susceptibility of lung cancer (P < 0> 24, squamous carcinoma) of CYP2C9 decreased lung cancer risk (P &lt; 0.05). In addition, two blocks of CYP2J2 and one block of CYP2C9 had strong linkages with increased risk of lung cancer. other: The authors had no conflicts of interest to declare.