Circulating tumor cell associated white blood cell cluster as a biomarker for metastasis and recurrence in hepatocellular carcinoma

医学 肝细胞癌 循环肿瘤细胞 转移 白细胞 肿瘤科 内科学 生物标志物 癌症 胃肠病学 病理 生物 生物化学
作者
Jing Chen,Yuhong Luo,Xiaoxue Xi,Haixia Li,Shufen Li,Lei Zheng,Dinghua Yang,Zhen Cai
出处
期刊:Frontiers in Oncology [Frontiers Media]
卷期号:12 被引量:11
标识
DOI:10.3389/fonc.2022.931140
摘要

Recently, an in vivo study demonstrated that circulating tumor cell-associated white blood cell (CTC-WBC) cluster possess much greater potential than single CTCs. We aim to explore the correlation between the CTC-WBC cluster and the clinicopathological characteristics of hepatocellular carcinoma (HCC) patients to seek novel biomarkers for HCC metastasis and recurrence.We retrospectively analyzed 136 HCC patients from October 2014 to March 2020 who received CTC tests using the CanPatrol CTC enrichment technique. The correlation between the clinical features and total CTCs, EMT-CTCs, and CTC-WBC cluster were analyzed by a chi-square test. The ROC curves were simulated for evaluating the diagnostic performance of CTC parameters in HCC metastasis. Patients were followed up from February 2015 to November 2021, and the relapse-free survival (RFS) was analyzed using the Kaplan-Meier curve.A total of 93.4% (127/136) and 31.6% (43/136) of HCC patients had detectable CTCs and CTC-WBC clusters. Baseline CTC-WBC cluster was closely correlated with microvascular invasion, portal vein tumor thrombus, and extrahepatic metastasis in pre-treatment HCC patients (P <0.05). The simulated ROC curves presented an AUC of 0.821 for the CTC-WBC cluster (sensitivity of 90.0% and specificity of 93.7%) in discriminating metastasis from non-metastatic HCC, which was higher than that for total CTCs (0.718) and EMT-CTCs (0.716). Further follow-up analysis showed that compared to the CTC-WBC cluster negative group (<1/5 ml), patients in the CTC-WBC cluster positive group (≥1/5 ml) presented an increased relapse ratio (60.0% versus 17.9%) and shorter RFS (22.9 versus 53.8 months). Dynamic analysis of CTCs parameters showed that total CTC level, EMT-CTCs proportion, and CTC-WBC cluster were decreased after microwave ablation treatment, while CTC-WBC cluster increased on average 10 months in advance of imaging (MRI) diagnosed recurrence.The CTC-WBC cluster is a promising biomarker for the metastasis diagnosis and prognosis of HCC metastasis. Dynamic monitoring of the CTC-WBC cluster is an effective method for early detection and intervention of HCC recurrence and metastasis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
可爱的函函应助香蕉静芙采纳,获得10
刚刚
张浩发布了新的文献求助10
刚刚
1秒前
fei发布了新的文献求助150
1秒前
2秒前
2秒前
3秒前
依灵完成签到,获得积分10
3秒前
3秒前
充电宝应助mariawang采纳,获得10
4秒前
王哈哈关注了科研通微信公众号
5秒前
kkdkg发布了新的文献求助10
5秒前
时笙发布了新的文献求助10
5秒前
苏利文完成签到,获得积分10
6秒前
6秒前
小二郎应助尔尔采纳,获得30
6秒前
7秒前
小丑鱼儿发布了新的文献求助10
7秒前
8秒前
Rubby应助Sissi采纳,获得10
8秒前
9秒前
隐形夕阳发布了新的文献求助50
10秒前
搞学术的发布了新的文献求助10
10秒前
Freddie发布了新的文献求助10
12秒前
淡淡梦容发布了新的文献求助10
12秒前
12秒前
mmol发布了新的文献求助10
13秒前
可靠的冰烟完成签到,获得积分10
13秒前
Ava应助kkdkg采纳,获得10
14秒前
Bio应助AA简单男孩采纳,获得26
15秒前
搜集达人应助虚幻靖易采纳,获得10
15秒前
Notdodead应助yyds采纳,获得10
15秒前
科研通AI2S应助Lu采纳,获得10
15秒前
16秒前
16秒前
搞怪的人龙完成签到,获得积分10
17秒前
淡淡梦容完成签到,获得积分10
17秒前
情怀应助star采纳,获得10
18秒前
19秒前
19秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021