肾透明细胞癌
代谢组学
肾细胞癌
疾病
肾癌
生物信息学
医学
代谢途径
癌症
计算生物学
生物
肿瘤科
内科学
新陈代谢
作者
Nicola Antonio di Meo,Francesco Lasorsa,Monica Rutigliano,Davide Loizzo,Matteo Ferro,Alessandro Stella,Cinzia Bizzoca,Leonardo Vincenti,Savio Domenico Pandolfo,Riccardo Autorino,Felice Crocetto,E. Montanari,Marco Spilotros,Michele Battaglia,Pasquale Ditonno,Giuseppe Lucarelli
标识
DOI:10.3390/ijms232214360
摘要
Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer subtype. Over the last decade, significant progress has been made in identifying the genetic and metabolic alterations driving ccRCC development. In particular, an integrated approach using transcriptomics, metabolomics, and lipidomics has led to a better understanding of ccRCC as a metabolic disease. The metabolic profiling of this cancer could help define and predict its behavior in terms of aggressiveness, prognosis, and therapeutic responsiveness, and would be an innovative strategy for choosing the optimal therapy for a specific patient. This review article describes the current state-of-the-art in research on ccRCC metabolic pathways and potential therapeutic applications. In addition, the clinical implication of pharmacometabolomic intervention is analyzed, which represents a new field for novel stage-related and patient-tailored strategies according to the specific susceptibility to new classes of drugs.
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