新皮层
前脑
脊椎动物
生物
黑鱼
蝾螈
平菇
神经科学
大脑
进化生物学
解剖
两栖动物
古生物学
中枢神经系统
动物
遗传学
基因
作者
Jamie Woych,Alonso Ortega Gurrola,Astrid Deryckere,Eliza C.B. Jaeger,Elias Gumnit,Gianluca Merello,Jiacheng Gu,Alberto Joven,Nicholas D. Leigh,Maximina H. Yun,András Simon,Maria Antonietta Tosches
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2022-09-01
卷期号:377 (6610)
被引量:51
标识
DOI:10.1126/science.abp9186
摘要
The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these innovations arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell-type atlas of the telencephalon of the salamander Pleurodeles waltl . Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. By contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex yet shares similarities with the entorhinal cortex and subiculum. Our findings chart the series of innovations that resulted in the emergence of the mammalian six-layered neocortex and the sauropsid DVR.
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