细胞器
生物
细胞生物学
细胞器生物发生
生物发生
细胞质
膜接触部位
膜蛋白
膜
遗传学
基因
整体膜蛋白
作者
Gia K. Voeltz,Eric M. Sawyer,György Hajnóczky,William A. Prinz
出处
期刊:Cell
[Elsevier]
日期:2024-01-01
卷期号:187 (2): 257-270
被引量:6
标识
DOI:10.1016/j.cell.2023.11.040
摘要
Summary
The view of organelles and how they operate together has changed dramatically over the last two decades. The textbook view of organelles was that they operated largely independently and were connected by vesicular trafficking and the diffusion of signals through the cytoplasm. We now know that all organelles make functional close contacts with one another, often called membrane contact sites. The study of these sites has moved to center stage in cell biology as it has become clear that they play critical roles in healthy and developing cells and during cell stress and disease states. Contact sites have important roles in intracellular signaling, lipid metabolism, motor-protein-mediated membrane dynamics, organelle division, and organelle biogenesis. Here, we summarize the major conceptual changes that have occurred in cell biology as we have come to appreciate how contact sites integrate the activities of organelles.
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