脂质体
纳米载体
药物输送
Zeta电位
生物相容性
药理学
贝伐单抗
生物医学工程
眼药水
粒径
药品
化学
纳米技术
医学
材料科学
外科
纳米颗粒
化疗
有机化学
物理化学
作者
Umer Farooq,Niall J. O’Reilly,Zubair Ahmed,Paolo Gasco,Thakur Raghu Raj Singh,Gautam Behl,Laurence Fitzhenry,Peter McLoughlin
标识
DOI:10.1016/j.ijpharm.2024.123958
摘要
Clinicians face numerous challenges when delivering medications to the eyes topically because of physiological barriers, that can inhibit the complete dose from getting to the intended location. Due to their small size, the ability to deliver drugs of different polarities simultaneously, and their biocompatibility, liposomes hold great promise for ocular drug delivery. This study aimed to develop and characterise a dual loaded liposome formulation encapsulating Bevacizumab (BEV) and Dexamethasone (DEX) that possessed the physicochemical attributes suitable for topical ocular delivery. Liposomes were prepared by using thin film hydration followed by extrusion, and the formulations were optimised using a design of experiments approach. Physicochemical characterisation along with cytocompatibility and bioactivity of the formulations were assessed. Liposomes were successfully prepared with a particle size of 139 ± 2 nm, PDI 0.03 ± 0.01 and zeta potential −2 ± 0.7 mV for the optimised formulation. BEV and DEX were successfully encapsulated into the liposomes with an encapsulation efficiency of 97 ± 0.5 % and 26 ± 0.5 %, respectively. A sustained release of BEV was observed from the liposomes and the bioactivity of the formulation was confirmed using a wound healing assay. In summary, a potential topical eye drop drug delivery system, which can co-load DEX and BEV was developed and characterised for its potential to be used in ocular drug delivery.
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